Document Type : Original Article
Authors
1
Pharmacology Department, Faculty of Veterinary Medicine, New Valley University, New Valley, Egypt.
2
Biochemistry and Molecular Biology Department, Faculty of Veterinary Medicine, New Valley University, New Valley, Egypt
3
Chemistry, Nutritional Deficiency and Toxicology Department, Animal Health Research Institute, El-Dakhla, New Valley, Egypt
Abstract
The kidney is an essential part of the urinary system responsible for hormone secretion and blood filtration from waste products. Nephrotoxicity (NEP) is one of the most popular kidney diseases and originates from environmental toxic agents and a wide spectrum of therapeutic drugs. Olive oil (OO) is among the natural oils extracted from olives. It offers many health benefits against chronic diseases and has an immunostimulant role. The study was designed to predict the reno-protective impact of OO opposing NEP.
The research model was performed using three groups of adult male albino rats (n=10); the control group, NEP induced group by carbon tetrachloride, and the third group protected against NEP by OO. Kidney function was evaluated by measuring serum urea, creatinine, uric acid, and electrolytes. Further, the oxidative stress parameters, thiobarbituric acid reactive substances, nitric oxide, and reduced glutathione were analyzed in renal tissue homogenate. In addition, the ELISA technique assessed both tumor necrosis factor-alpha and interleukin-6. The histopathological study of renal tissue was also inspected.
The results demonstrated that OO has an excellent protective effect, such as greatly restoring the higher level of kidney parameters and oxidative stress injury. Further, OO declined the induced inflammation and fibrosis in the protective group compared to NEP.
Therefore, due to OO promising nephroprotective potentiality, it could be used to avoid disorders linked to oxidative stress. It is strongly recommended to conduct further research on its application.
Keywords
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