The effect of Norethisterone Acetate (NETA) on the ovarian follicles of albino rats: Histological Study.

Document Type : Original Article


1 Department of Anatomy and Histology, faculty of Veterinary medicine, New Valley University, kharga, Egypt

2 Department of cell and tissue, Faculty of Veterinary Medicine, Assiut University.

3 Department of Animal and environmental Hygiene, Faculty of Veterinary medicine, Assiut University.


Background: Norethisterone, also known as norethisterone acetate, NETA, or norethindrone, is a commonly used progestogen in various European countries.
Aim of the Work: Studies have shown that introducing synthetic hormones can alter the effects of sex hormones and lead to negative outcomes for the ovaries. There is a lack of histology reports regarding the effects of norethisterone acetate (NETA) exposure. So, the present study focuses on histological sequelae following exposure to norethisterone acetate in the albino rats' ovary.
Materials and Methods: Fourteen Adult female albino rats, grouped into A and B were investigated. A control consisted of 7 rats and A treated group consisted of 7 rats. Control group ( A) rats were administered daily food and distilled water only while Treated group (B) rats were administered daily 20 µg of norethisterone acetate, food, and water daily for three weeks.
Results: The findings indicate that the use of norethisterone acetate has negative effects on the ovarian follicles, including a reduction in their number and signs of atresia across all stages.
Conclusion: This treatise underscored norethisterone acetate has an adverse effect on the follicular development of the rat's ovary